A singular mutation in the hemagglutinin of the 1918 pandemic virus.
Identifieur interne : 000285 ( France/Analysis ); précédent : 000284; suivant : 000286A singular mutation in the hemagglutinin of the 1918 pandemic virus.
Auteurs : Yves-Henri Sanejouand [France]Source :
- Archives of biochemistry and biophysics [ 1096-0384 ] ; 2017.
Descripteurs français
- KwdFr :
- MESH :
- génétique : Glycoprotéine hémagglutinine du virus influenza, Sous-type H1N1 du virus de la grippe A.
- virologie : Grippe humaine.
- épidémiologie : Grippe humaine.
- Humains, Modèles moléculaires, Mutation ponctuelle, Pandémies, Substitution d'acide aminé.
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : Hemagglutinin Glycoproteins, Influenza Virus.
- epidemiology : Influenza, Human.
- genetics : Influenza A Virus, H1N1 Subtype.
- virology : Influenza, Human.
- Amino Acid Substitution, Humans, Models, Molecular, Pandemics, Point Mutation.
Abstract
The influenza pandemic of 1918-1919 killed at least 50 million people. The reasons why this pandemic was so deadly remain largely unknown [9]. However, It has been shown that the 1918 viral hemagglutinin allows to reproduce the hallmarks of the illness observed during the original pandemic [11]. Thanks to the wealth of hemagglutinin sequences accumulated over the last decades, amino-acid substitutions that are found in the 1918-1919 sequences but rare otherwise can be identified with high confidence. Noteworthy, Gly 188, which is located within a key motif of the receptor binding site, has never been observed again in sequences of human viruses of subtype H1. Monitoring this singular mutation in viral sequences may help prevent another dramatic pandemic.
Url:
DOI: 10.1016/j.abb.2017.05.013
PubMed: 28577911
Affiliations:
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pubmed:28577911Le document en format XML
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Electronic address: yves-henri.sanejouand@univ-nantes.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>UFIP, UMR 6286 of CNRS, Faculté des Sciences et des Techniques, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author></analytic><series><title level="j">Archives of biochemistry and biophysics</title><idno type="eISSN">1096-0384</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Substitution</term><term>Hemagglutinin Glycoproteins, Influenza Virus (genetics)</term><term>Humans</term><term>Influenza A Virus, H1N1 Subtype (genetics)</term><term>Influenza, Human (epidemiology)</term><term>Influenza, Human (virology)</term><term>Models, Molecular</term><term>Pandemics</term><term>Point Mutation</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Glycoprotéine hémagglutinine du virus influenza (génétique)</term><term>Grippe humaine (virologie)</term><term>Grippe humaine (épidémiologie)</term><term>Humains</term><term>Modèles moléculaires</term><term>Mutation ponctuelle</term><term>Pandémies</term><term>Sous-type H1N1 du virus de la grippe A (génétique)</term><term>Substitution d'acide aminé</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Hemagglutinin Glycoproteins, Influenza Virus</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Glycoprotéine hémagglutinine du virus influenza</term><term>Sous-type H1N1 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Substitution</term><term>Humans</term><term>Models, Molecular</term><term>Pandemics</term><term>Point Mutation</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Humains</term><term>Modèles moléculaires</term><term>Mutation ponctuelle</term><term>Pandémies</term><term>Substitution d'acide aminé</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The influenza pandemic of 1918-1919 killed at least 50 million people. The reasons why this pandemic was so deadly remain largely unknown [9]. However, It has been shown that the 1918 viral hemagglutinin allows to reproduce the hallmarks of the illness observed during the original pandemic [11]. Thanks to the wealth of hemagglutinin sequences accumulated over the last decades, amino-acid substitutions that are found in the 1918-1919 sequences but rare otherwise can be identified with high confidence. Noteworthy, Gly 188, which is located within a key motif of the receptor binding site, has never been observed again in sequences of human viruses of subtype H1. Monitoring this singular mutation in viral sequences may help prevent another dramatic pandemic.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Pays de la Loire</li></region><settlement><li>Nantes</li></settlement></list><tree><country name="France"><region name="Pays de la Loire"><name sortKey="Sanejouand, Yves Henri" sort="Sanejouand, Yves Henri" uniqKey="Sanejouand Y" first="Yves-Henri" last="Sanejouand">Yves-Henri Sanejouand</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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